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Across the course of a year, Laura took photos of the vulvas for her book Womanhood: The Bare Reality, and spoke to each person about what their vulva means to them. Some of the women involved have also been featured in a film for Channel 4 called Vaginas. Then she examined masculinity by photographing penises for Manhood. And after that, Laura considered the project complete. But reading about Female Genital Mutilation, the number of women speaking surgery on their vulvas and the language around how we refer to female body parts made Laura reconsider.
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Access to readily available large animal models and sensitive non-invasive techniques that can be used for the evaluation of microbicide-induced changes in tissue could significantly facilitate pre-clinical evaluations of microbicide safety. The sheep cervicovaginal tract, with stratified squamous epithelium similar to humans, holds promise as a large animal model used prior to non-human primates. In addition, optical coherence tomography OCT could enable high resolution visualization of tissue morphology and non-invasive assessment of microbicide-induced epithelial injury. We evaluated the dose response of sheep cervicovaginal tract to benzalkonium chloride BZK. Pre- and post-treatment colposcopy and OCT images were collected and graded based on WHO criteria and a previously reported scoring system, respectively. Biopsies were collected and the degree of epithelial injury and its thickness was assessed based on histology and OCT. The sheep cervicovagina exhibited anatomical and microscopic features similar to the human.
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